Retinal involvement in sepsis: from the eye of the patient to the …
Jun 17, 2017 · In Greek mythology the symbolic value of the eye was already supported by detailed medical knowledge . Not only symbolizing the giant one-eyed cyclops’ limited intelligence in contrast to the vigilance of Panoptes, whose body was covered by eye’s, the stories also reflected the understanding of the concepts of visual fields and acuity.
The association between the presence and burden of periodic …
May 9, 2023 · Background Sepsis-associated encephalopathy (SAE) is frequent in septic patients. Electroencephalography (EEG) is very sensitive to detect early epileptic abnormalities, such as seizures and periodic discharges (PDs), and to quantify their duration (the so-called burden). However, the prevalence of these EEG abnormalities in septic patients, as well as their effect on morbidity and mortality ...
Pattern of Brain Injury in the Acute Setting of Human Septic Shock
Sep 18, 2013 · Background Sepsis-associated brain dysfunction has been linked to white matter lesions (leukoencephalopathy) and ischemic stroke. Our objective was to assess the prevalence of brain lesions in septic shock patients requiring magnetic resonance imaging (MRI) for an acute neurologic change. Method Seventy-one septic shock patients were included in a prospective observational study. Patients ...
Fluid management for sepsis-induced hypotension in patients with ...
Jul 11, 2024 · Background Early fluid management in patients with advanced chronic kidney disease (CKD) and sepsis-induced hypotension is challenging with limited evidence to support treatment recommendations. We aimed to compare an early restrictive versus liberal fluid management for sepsis-induced hypotension in patients with advanced CKD. Methods This post-hoc analysis included patients with advanced CKD ...
The role of endotoxin in septic shock - Critical Care
Oct 19, 2023 · Septic shock can be caused by a variety of mechanisms including direct effects of bacterial toxins such as endotoxin. Annually, approximately 5–7 million patients worldwide develop sepsis with very high endotoxin activity in the blood and more than half die. The term endotoxic septic shock has been used for these patients but it is important to emphasize that endotoxin may be a factor in all ...
Clinical review: The liver in sepsis | Critical Care | Full Text
Oct 30, 2012 · During sepsis, the liver plays a key role. It is implicated in the host response, participating in the clearance of the infectious agents/products. Sepsis also induces liver damage through hemodynamic alterations or through direct or indirect assault on the hepatocytes or through both. Accordingly, liver dysfunction induced by sepsis is recognized as one of the components that contribute to ...
Neurofilament light chains to assess sepsis-associated …
May 31, 2023 · Sepsis is the most common cause of admission to intensive care units worldwide. Sepsis patients frequently suffer from sepsis-associated encephalopathy (SAE) reflecting acute brain dysfunction. SAE may result in increased mortality, extended length of hospital stay, and long-term cognitive dysfunction. The diagnosis of SAE is based on clinical assessments, but a valid biomarker to identify and ...
The incidence and outcome of septic shock patients in the …
May 16, 2006 · Introduction The purpose of the present study was to measure the incidence and outcome of septic patients presenting at the emergency department (ED) with criteria for early goal-directed therapy (EGDT). Method This hospital-based, retrospective, observational study using prospectively collected electronic databases was based in a teaching hospital in Melbourne, Australia. We conducted outcome ...
Unraveling the role of HIF-1α in sepsis: from pathophysiology to ...
Mar 27, 2024 · Sepsis is characterized by organ dysfunction resulting from a dysregulated inflammatory response triggered by infection, involving multifactorial and intricate molecular mechanisms. Hypoxia-inducible factor-1α (HIF-1α), a notable transcription factor, assumes a pivotal role in the onset and progression of sepsis. This review aims to furnish a comprehensive overview of HIF-1α's mechanism of ...
Infectious disease-associated encephalopathies - Critical Care
Jul 6, 2021 · Infectious diseases may affect brain function and cause encephalopathy even when the pathogen does not directly infect the central nervous system, known as infectious disease-associated encephalopathy. The systemic inflammatory process may result in neuroinflammation, with glial cell activation and increased levels of cytokines, reduced neurotrophic factors, blood–brain barrier dysfunction ...