Respiratory syncytial virus: from pathogenesis to potential …
First-in-Human Randomized Study to Assess the Safety and Immunogenicity of an Investigational Respiratory Syncytial Virus (RSV) Vaccine Based on Chimpanzee-Adenovirus-155 Viral Vector-Expressing RSV Fusion, Nucleocapsid, and Antitermination Viral Proteins in Healthy Adults.
Respiratory syncytial virus - Wikipedia
Respiratory syncytial virus (RSV), [a] also called human respiratory syncytial virus (hRSV) and human orthopneumovirus, is a contagious virus that causes infections of the respiratory tract. It is a negative-sense, single-stranded RNA virus. [2]
Structural landscape of the respiratory syncytial virus ... - Nature
Sep 15, 2023 · Human Respiratory Syncytial Virus (HRSV) is a prevalent cause of severe respiratory infections in children and the elderly. The helical HRSV nucleocapsid is a template for the viral RNA...
Respiratory syncytial virus entry and how to block it
Feb 5, 2019 · Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract disease in young children and elderly people. Although the virus was isolated in 1955, an effective RSV...
Structural Analysis of Respiratory Syncytial Virus Reveals the …
Respiratory syncytial virus (RSV), a member of the Paramyxoviridae family of nonsegmented, negative-sense, single-stranded RNA genome viruses, is a leading cause of lower respiratory tract infections in infants, young children, and the elderly or immunocompromised.
Standardized Phylogenetic Classification of Human Respiratory …
Jun 21, 2024 · Figure 1. The structure and genome of human respiratory syncytial virus (HRSV). A) Schematic of the HRSV virion structure detailing the location of structural proteins. B) Schematic of the HRSV genome organization... In 2022, HRSV was designated as Orthopneumovirus hominis species within the Pneumoviridae family.
IGF1R is an entry receptor for respiratory syncytial virus
Jun 3, 2020 · Respiratory syncytial virus enters cells by binding to cell-surface IGFR1, which activates PKCζ and induces trafficking of the NCL coreceptor to the RSV particles at the cell surface.
The Morphology and Assembly of Respiratory Syncytial Virus
Aug 20, 2018 · RSV is a pleomorphic enveloped RNA virus in the Pneumoviridae family. Recently, the three-dimensional (3D) structure of purified RSV particles has been elucidated, revealing three distinct morphological categories: spherical, asymmetric, and filamentous.
Figure 1. The schematic diagram of the genome organization and RNA synthesis of RSV. The leader (Le, cyan) and trailer (Tr, gold) are at 30 and 50 ends of the genome. The genes N, P, M2, L (blue), NS1, NS2, M, SH, G, and F (gray) are flanked …
Structure and function of respiratory syncytial virus surface ...
In this chapter, we review the structure and function of the RSV surface glycoproteins, including recent X-ray crystallographic data of the F glycoprotein in its pre- and postfusion conformations, and discuss how this information informs antigen selection and vaccine development.