Nov 4, 2022 · We enrolled patients with chronic kidney disease who had an estimated glomerular filtration rate (eGFR) of at least 20 but less than 45 ml per minute per 1.73 m 2 of body-surface …

May 18, 2025 · A total of 1177 patients underwent randomization, of whom 77.7% were taking nintedanib or pirfenidone at enrollment. Adjusted mean changes in FVC at week 52 were …

Apr 11, 2022 · Neoadjuvant or adjuvant chemotherapy confers a modest benefit over surgery alone for resectable non–small-cell lung cancer (NSCLC). In early-phase trials, nivolumab …

Sep 1, 2024 · Over a median follow-up of 32 months, 1083 primary-outcome events occurred in 624 of 3003 patients in the finerenone group, and 1283 primary-outcome events occurred in …

Aug 27, 2022 · Few pharmacologic treatment options exist for patients with heart failure and a mildly reduced or preserved left ventricular ejection fraction. 5,6 Recently, treatment with the …

Aug 27, 2021 · In this double-blind trial, we randomly assigned 5988 patients with class II–IV heart failure and an ejection fraction of more than 40% to receive empagliflozin (10 mg once …

Sep 24, 2020 · The independent data monitoring committee recommended stopping the trial because of efficacy. Over a median of 2.4 years, a primary outcome event occurred in 197 of …

Aug 25, 2023 · We randomly assigned 529 patients who had heart failure with preserved ejection fraction and a body-mass index (the weight in kilograms divided by the square of the height in …

May 12, 2021 · Approximately 10% of patients with asthma have severe disease and have symptoms and exacerbations despite treatment with maximal standard-of-care controller …

Nov 26, 2015 · A total of 7020 patients were treated (median observation time, 3.1 years). The primary outcome occurred in 490 of 4687 patients (10.5%) in the pooled empagliflozin group …