Cubs left-hander Shota Imanaga turned to look over his left shoulder at the video board showing the replay of the home run he just had given up in the fourth inning Friday. In a game the Cubs would go on to lose 12-5 to the White Sox, it was the third homer Imanaga had yielded, all on fastballs that caught too much of the strike zone.

Pregame analysis and predictions of the Chicago Cubs vs. Chicago White Sox MLB game to be played on July 26, 2025 on ESPN.

Rookie Edgar Quero had his first four-hit game, rookie Chase Meidroth homered among his three hits, and the Chicago White Sox beat Shota Imanaga and the crosstown Cubs 12-5 on Friday night for their sixth win in seven games.