A 59-year-old man was brought to the emergency department after a motor vehicle collision. Paradoxical movement of a segment of his chest wall during respiration was noted on examination (shown in ...

A total of 187 patients underwent randomization. Of these patients, 40% had non–small-cell lung cancer, 32% had pancreatic cancer, and 29% had colorectal cancer. At 12 weeks, patients in the ...

In this audio interview, Editor-in-Chief Eric Rubin and NEJM Evidence Associate Editor Oladapo Yeku discuss research being presented at the 2024 European Society of Medical Oncology annual meeting.

Pragmatic and cluster RCTs offer opportunities for advancing research but present ethical challenges. Addressing these challenges requires multidisciplinary expertise and meaningful collaboration.

A chance encounter with a retired military officer who recently lost his wife to cancer raises questions for a retired pediatrician about medical hierarchy, team leadership, and appropriate care.

Sensitivity analyses are instrumental in assessing the robustness of trial findings. Thoughtful planning is needed to ensure they are conducted and reported properly. The views expressed in this ...

After your institutional site license order is processed, you will receive an email that contains your NEJM account information and customer number. Use the link provided to begin the activation ...

In Western countries, the current standard of care for resectable gastric cancer is perioperative chemotherapy. Preoperative chemoradiotherapy has been considered, but data are limited regarding ...

The addition of pembrolizumab to trastuzumab and chemotherapy in patients with gastric cancer improved both progression-free and overall survival as compared with trastuzumab and chemotherapy alone.

Adjuvant therapy with durvalumab, with or without tremelimumab, may have efficacy in patients with limited-stage small-cell lung cancer who do not have disease progression after standard ...

In this audio interview, Editor-in-Chief Eric Rubin and NEJM Evidence Associate Editor Oladapo Yeku discuss research being presented at the 2024 European Society of Medical Oncology annual meeting.

In this audio interview, Editor-in-Chief Eric Rubin and NEJM Evidence Associate Editor Oladapo Yeku discuss research being presented at the 2024 European Society of Medical Oncology annual meeting.