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Systematic review and meta-analysis of the efficacy of biologic and targeted synthetic therapies in sarcoidosis
Objectives Infliximab, an anti-TNF agent, is used to treat sarcoidosis that does not respond to corticosteroids or second-line agents. The efficacy of other anti-TNF agents, non-TNF biologics and ...
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Tocilizumab, sarilumab and anakinra in critically ill patients with COVID-19: a randomised, controlled, open-label, adaptive platform trial
Introduction Tocilizumab improves outcomes in critically ill patients with COVID-19. Whether other immune-modulator strategies are equally effective or better is unknown. Methods We investigated ...
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Effect of viloxazine and trazodone in obstructive sleep apnoea: a randomised, placebo-controlled, cross-over study
Introduction Combination of the noradrenergic atomoxetine with either the antimuscarinic aroxybutynin or trazodone has been shown to improve obstructive sleep apnoea (OSA) severity. However, ...
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Severe community-acquired pneumonia (sCAP): advances in management and future directions
Severe community-acquired pneumonia (sCAP) is a major global health challenge, with high morbidity and mortality, especially among patients requiring intensive care. Despite advancements in ...
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Urban air pollution, and asthma and COPD hospital emergency room visits
Background: There is little previous information of the effects of size fractioned particulate air pollution and source specific fine particles (PM 2.5; <2.5 μm) on asthma and chronic obstructive ...
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Acute respiratory failure secondary to chronic obstructive pulmonary disease treated in the intensive care unit: a long term follow up study
4 Department of Respiratory Medicine, Royal Prince Alfred Hospital, Sydney, Australia Correspondence to: Dr D Breen, Intensive Care Unit, Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW ...
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Prospective comparison of three predictive rules for assessing severity of community-acquired pneumonia in Hong Kong
1 Accident and Emergency Medicine Academic Unit, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong 2 Department of Medicine and Therapeutics, Chinese University of Hong ...
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Guidelines on the selection of patients with lung cancer for surgery
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External validation and recalibration of the Brock model to predict probability of cancer in pulmonary nodules using NLST data
Correspondence to Dr Audrey Winter, Department of Radiological Sciences, Medical Imaging Informatics, University of California, Los Angeles, CA 90095, USA; audrey.winter89{at}gmail.com Introduction We ...
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Midlife cardiorespiratory fitness and the long-term risk of chronic obstructive pulmonary disease
1 Herlev-Gentofte University Hospital, Medical Department O, Respiratory Section; Herlev-Gentofte University Hospital, Department of Cardiology, Copenhagen, Denmark 2 The Copenhagen Male Study ...