BMJ23h
Mechanical overloading promotes chondrocyte senescence and osteoarthritis development through downregulating FBXW7
Objectives To investigate the role of mechanical stress in cartilage ageing and identify the mechanistic association during osteoarthritis (OA) progression. Conclusions FBXW7 is a key factor in the ...
BMJ1d
Global, regional and national burden of osteoarthritis 1990-2017: a systematic analysis of the Global Burden of Disease Study 2017
Objectives To report the level and trends of prevalence, incidence and years lived with disability (YLDs) for osteoarthritis (OA) in 195 countries and territories from 1990 to 2017 by age, sex and ...
BMJ2d
2019 European League Against Rheumatism/American College of Rheumatology classification criteria for systemic lupus erythematosus
Correspondence to Martin Aringer, Medicine III, University Medical Center and Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden D-01307, Germany; martin.aringer{at}uniklinikum-dresden.de; Dr ...
BMJ3d
OP0260 Targeting CD1C-Expressing MDCS to Inhibit T Cell Activation and Thymus and Activation Regulated Chemokine (TARC)-Dependent Chemotaxis in RA
Background Recently, we demonstrated strong Th1 and Th17 cytokine induction by CD1c + myeloid dendritic cells (mDCs) from synovial fluid and identified thymic stromal lympopoeitin (TSLP) as an ...
BMJ3d
Molecular signature characterisation of different inflammatory phenotypes of systemic juvenile idiopathic arthritis
Objectives The International League of Associations for Rheumatology classification criteria define systemic juvenile idiopathic arthritis (SJIA) by the presence of fever, rash and chronic arthritis.
BMJ3d
Tofacitinib for the treatment of ankylosing spondylitis: a phase III, randomised, double-blind, placebo-controlled study
Objective To assess the efficacy/safety of tofacitinib in adult patients with active ankylosing spondylitis (AS). Methods This phase III, randomised, double-blind, placebo-controlled study enrolled ...
BMJ4d
Myeloablation followed by autologous stem cell transplantation normalises systemic sclerosis molecular signatures
Objective In the randomised scleroderma: Cyclophosphamide Or Transplantation (SCOT trial) (NCT00114530), myeloablation, followed by haematopoietic stem cell transplantation (HSCT), led to improved ...
BMJ4d
Morbidity and mortality in the antiphospholipid syndrome during a 10-year period: a multicentre prospective study of 1000 patients
Objectives To assess the prevalence of the main causes of morbi-mortality in the antiphospholipid syndrome (APS) during a 10-year-follow-up period and to compare the frequency of early manifestations ...
BMJ4d
Acute phase response in familial Mediterranean fever
1 Department of Rheumatology, Medical School of Osmangazi University, Eskisehir, Turkey 2 Department of Rheumatology, Cerrahpasa Medical School, University of Istanbul, Turkey 3 Department of ...
BMJ4d
Raised serum APRIL levels in patients with systemic lupus erythematosus
Objective: To determine whether serum levels of a proliferation-inducing ligand (APRIL) are raised in patients with systemic lupus erythematosus (SLE) and correlate with autoantibody titres or disease ...
BMJ4d
AB1006 IMPACT OF OSTEOARTHRITIS ON THE QUALITY OF LIFE IN PATIENTS WITH KNEE PAIN
Background Knee osteoarthritis is a common disease which mainly concerns aged population and impairs the quality of life in all aspects. Apart from causing pain or other related biomechanical ...
BMJ5d
Long-term outcome of a randomised controlled trial comparing tacrolimus with mycophenolate mofetil as induction therapy for active lupus nephritis
Objectives To report the 10-year outcome of lupus nephritis (LN) treated with mycophenolate mofetil (MMF) or tacrolimus (TAC) induction in a randomised controlled trial. Methods Patients with active ...