How does the cell convert DNA into working proteins? The process of translation can be seen as the decoding of instructions for making proteins, involving mRNA in transcription as well as tRNA. But ...
Translocation: The ribosome moves one codon down the mRNA. The tRNA in the A site moves to the P site, the tRNA in the P site ...
Optimizing dsRNA Removal in IVT mRNA: Strategies for Enhanced Translation and Reduced Immunogenicity
Double-stranded RNA (dsRNA) is a well-recognized byproduct of in vitro transcription that poses significant challenges for the use of synthetic mRNA in research and therapeutic applications. Even ...
In a recent study published in Nature, a group of researchers explored how the incorporation of N1-methylpseudouridine (1-methylΨ) into messenger ribonucleic acids (mRNAs) affects ribosomal ...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a beta-CoV that recently emerged as a human pathogen and is the causative agent of the COVID-19 pandemic. A molecular framework of how ...
Erythropoietin (EPO) is a 30.4 kDa glycoprotein comprised of one 165 amino acid residues chain with four glycosylation locations (Figure 1). The hormone is produced naturally in the kidneys, ...
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