The growing incidence of infectious diseases, cancer, and chronic illnesses has substantially increased the demand for ...

In the last decade, a series of studies highlighted the powerful potential of combining mRNA modification with lipid nanoparticle technologies, which led to the first approval of an LNP-mRNA vaccine.

The mRNA metabolism passively shapes the levels of an mRNA modification called m6A within a steady-state cell and upon stress.

Liquid-liquid phase separation (LLPS) has emerged as a major organizing principle in cells. Recent work showed that multiple components of integrin-mediated focal adhesions, including p130Cas can form ...

A research team from The University of Osaka and the Institute of Science Tokyo has developed a class of mRNA medicines that ...

Summary: New research reveals how a tiny chemical mark on RNA helps wire the brain during development. Scientists discovered ...

More information: Aseno Sakhrie et al, Nanoparticle-Based mRNA Vaccine Induces Protective Neutralizing Antibodies Against Infectious Bronchitis Virus in In-Vivo Infection, Vaccines (2025).

PABP binds to the translation-initiation factor eIF4G, which in turn binds to the cap-binding protein eIF4E 3 (Fig. 1). The PABP–eIF4G–eIF4E interaction enhances mRNA translation.

Researchers develop a self-regulating mRNA medicine that adjusts protein production based on disease-related signals.

TriLink’s CleanCap technology produces optimal 5′ cap structures with over 95% efficiency, creating a co-transcriptional capping solution that dramatically improves mRNA yield and process time ...

Background Chronic inflammation and elevated reactive oxygen species are key contributors to hepatocellular carcinoma (HCC) ...