The first part of the production process is making that mRNA IVT construct. To do this, it is essential to first isolate viral nucleic acid or the pathogen of interest.

Professor Hirohide Saito and his research team have developed a new microRNA-responsive hybrid mRNA switch, enabling precise, ...

The mRNA market is projected to reach $63.28 billion by 2025, indicating an all-time high global demand for mRNA vaccines and therapeutics. Now more than ever, robust process development and ...

The mRNA production process There are several methods for synthesizing mRNA; but cell-free, low-cost, simple, and large-scale production is commonly achieved by in vitro transcription (IVT).

The success of the mRNA-based vaccines against SARS-CoV-2 merely hint at the healthcare implications of mRNA technology. More mRNA-based vaccines are in the works, as are mRNA-based therapeutics ...

A focused effort to overcome those production challenges resulted in mAbs becoming the fastest growing class of biopharmaceutical products. 6 A critical factor in driving mRNA forward is likely to ...

Creating mRNA with an all-chemical process may allow for customized mRNA vaccines Date: June 7, 2022 Source: Nagoya University Summary: A new synthesis method offers hope for creation of advance ...

Development of hydrophobic tag purifying monophosphorylated RNA for chemical synthesis of capped mRNA and enzymatic synthesis of circular mRNA. Nucleic Acids Research , 2024; DOI: 10.1093/nar/gkae847 ...

Researchers at the University of Würzburg have discovered a process that breaks down mRNA molecules in the human body particularly efficiently. This could be useful, for example, in the treatment ...

How to supercharge vaccine production for the next pandemic. To defeat the next pandemic, the world needs year-round facilities pumping out vaccines for threats old and new.

Making mRNA vaccine shots differs in significant ways from traditional vaccine production. It is an enzymatic process, not a biological one that involves live cells, and in many ways is closer to ...

In 2021, the World Health Organization set up an “mRNA production hub” at a small biotechnology company in Cape Town called Afrigen Biologics and Vaccines, with the goal of reverse-engineering ...