Rapamycin is mTORC1 inhibitor, but long-term exposure to rapamycin (>18 hours) could also inhibit mTORC2. RhoA signaling pathway is regulated through the mTORC2 pathway; thus we hypothesized that long ...

By inducing a non-canonical RhoA/ROCK signaling pathway, IL-1beta inhibits the ability of SARS-CoV-2 infected cells to fuse with uninfected cells and produce syncytia. Convincing evidence underlies ...

In return, Gilead will have global rights to develop, manufacture, and commercialize the small molecule oral STAT6 (signal transducer ... the potential of the STAT6 pathway to bring forward ...

7 refine our understanding of the signaling effects of oncogenic KRAS. Rather than activating multiple effectors, mutant KRAS signals preferentially through the RAF–MEK–ERK pathway ...

Scientists have uncovered a crucial pathway that links brain cell activity to the activation of genes responsible for ...

A research team led by Dr. Tetsuya Muramoto from the Faculty of Science at Toho University has demonstrated the mechanisms by which periodic chemical signal frequencies in cells regulate gene ...

A study published in the Journal of Neuroscience sheds new light on how brain cells relay critical information from their ...

Dihydromyricetin (Dih), a naturally occurring flavonoid, has been identified to exert a protective effect against ischemia/reperfusion injury. However, the detailed mechanisms remain unclear. Here we ...

ATLANTA — With just nine months left for the test pilot program, Gov. Brian Kemp said he’s proposing new legislation to adjust how the Georgia Pathways to Coverage program works and provide ...