Endoplasmic reticulum (ER) stress and Unfolded Protein Response (UPR) signaling promote the pathology of many human diseases. Loss-of-function variants of the UPR regulator Activating Transcription ...

A 291-day-old retina organoid. Red and green cone photoreceptors appear green, blue cone photorectors appear blue, and rod photoreceptors appear red. Scientists have grown simplified human retinas ...

So the team concluded that Pias3 promotes rod cell development and suppresses cone cell development. Next they wanted to know if Pias3 works the same in eye cells as it does in other cells, through ...

Humans rely on sight, which is primarily mediated by three color-sensing cone types, to perceive the world in a kaleidoscope of hues. Blue cones develop earliest, followed by the morphologically ...

Researchers at the Johns Hopkins University School of Medicine and Washington University School of Medicine have identified a key to eye development — a protein that regulates how the light-sensing ...

The vertebrate rod and cone photoreceptors are highly specialized sensory neurons that transduce light into the chemical and electrical signals of the nervous system. Although the physiological ...

Early mammals evolved in a burst during the Jurassic period, adapting a nocturnal lifestyle when dinosaurs were the dominant daytime predator. How these early mammals evolved night vision to find food ...