Cine was Kwesi Adofo-Mensah’s first draft pick as Vikings GM in 2022. He was projected to be a fit in Ed Donatell’s defense, which was part of the Vic Fangio system. Cine didn’t crack the initial starting lineup and was primarily a special teams player before suffering a compound leg fracture in London four games into the season.

The Philadelphia Eagles have signed former Georgia Bulldogs safety Lewis Cine off the Buffalo Bills' practice squad ahead of the NFL playoffs. Cine is the sixth Georgia Bulldog on the Eagles' active r

After his college career, Cine was selected with the No. 32 pick in the 2022 NFL draft by the Minnesota Vikings. In his rookie year, he suffered a lower leg injury that ended his season. After two years in Minnesota, Cine was released before the 2024 season began and was added to the Bills practice squad a few days later.