A new study reveals how a critical imbalance in bile acids—the substances made by the liver that help digest fats—can trigger ...

Most people have never heard of primary biliary cholangitis (PBC), but the progressive, rare cholestatic liver disease can ...

When these humanised organoids were transplanted into rodents whose own liver-bile duct system had been disconnected, the ...

The liver is the body's control tower for metabolism, powering vital functions like converting nutrients to glucose, storing fat and breaking down toxins. Over a third of the world, however, is ...

While organoids aim to mimic human organs, the liver's repertoire of complex functions – and thus the energy it needs to operate – have made it challenging for researchers to grow organoids that ...

Researchers suspected these gut microbial modifications could affect how bile acids function and interact with human ...

When pregnant women with common bile duct stones present with obstructive jaundice and ... stones or any other causes of obstruction before the initial closure, and the function of the major duodenal ...

Such spatially tailored hydrogels not only enhance cellular function and differentiation but also support the formation of biologically relevant zonal architecture, improving the physiological ...

Liver function is critical to maintaining health ... Certain conditions may affect the bile ducts. If the bile can't flow freely through the ducts, it may build up in the liver, causing damage.

Correspondence to Dr Daniela Sia, Division of Liver Diseases, Department of Medicine, Tisch Cancer Institute, Liver Cancer Program, Icahn School of Medicine at Mount Sinai, New York, New York, USA; ...