SIRT2, an enzyme previously overlooked in astrocytic GABA production, may be crucial for distinguishing the specific effects ...

Historically, bone has been recognized primarily for its structural role in the body, but emerging research suggests that it ...

Brain metastasis is emerging as the most serious concern for breast cancer patients. HER2-positive breast cancer is more prone to undergo brain metastasis than other subtypes; notably, there has been ...

Dizal will also present results from the ongoing Phase I/II study of DZD6008, a 4th generation EGFR TKI with full BBB penetration, in advanced EGFR mutation positive (EGFRm) non-small cell lung cancer ...

This study presents a valuable finding on the direct cytotoxic effects of DuoHexaBody-CD37 in diffuse large B-cell lymphoma, mediated via SHP-1 activation and antibody clustering, independent of ...

FDA clears Nurix Therapeutics, Inc.'s GS-6791 for inflammatory disorders; Nurix earns $5M milestone from Gilead. Click for my ...

IRAK4 has both kinase and scaffolding functions, thus complete pathway blockade requires an innovative ... clinical stage pipeline includes degraders of Bruton’s tyrosine kinase (BTK), a B-cell ...

In this work, the mechanism underlying the relationship between the mTOR signaling pathway and orthoflavivirus infection was reviewed from three perspectives: orthoflavivirus structure and life cycle, ...

The authors explained that while molecularly targeted therapies like Bruton tyrosine kinase (BTK) inhibitors and ... inhibitors can target aberrant signaling pathways and molecular defects ...

According to Trump, this exclusive card offers “a pathway to citizenship.” “We're gonna be selling a gold card. You have a green card, this is a gold card. We're gonna be putting a price on ...

CD47-amyloid-β-CD74 signaling is a key driver of adaptive immunosuppression in sepsis, suppressing B cells and impairing immunity. Blocking this pathway restores immune function and improves survival ...