Frontiers26d
Role of copper homeostasis and cuproptosis in heart failure pathogenesis: implications for therapeutic strategies
Excess intracellular copper is sequestered by two key molecules, MT and GSH. Copper is then exported from the cell by ATP7A/B, which relocates copper from the TGN to the plasma membrane, where it is ...
Pharmaceutical Technology27d
FDA accepts Sentynl’s Menkes disease therapy NDA for priority review
A rare genetic disorder affecting copper levels in the body, Menkes disease is caused by mutations in the ATPase Copper Transporting Alpha (ATP7A) gene. Give your business an edge with our leading ...
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Morningstar27d
Fortress Biotech and Cyprium Therapeutics Announce U.S. FDA Acceptance and Priority Review of NDA for CUTX-101 for Treatment of Menkes Disease
“Menkes disease presents a difficult journey for patients and their caregivers, as ATP7A mutations impact the transport of copper to a range of organs and systems, such as the lungs, brain and hear ...
Frontiers2mon
Targeting the initiator to activate both ferroptosis and cuproptosis for breast cancer treatment: progress and possibility for clinical application
Breast cancer is the most commonly diagnosed cancer worldwide. Metal metabolism is pivotal for regulating cell fate and drug sensitivity in breast cancer. Iron and copper are essential metal ions ...