Objectives To investigate the role of mechanical stress in cartilage ageing and identify the mechanistic association during osteoarthritis (OA) progression. Conclusions FBXW7 is a key factor in the ...

Objectives To report the level and trends of prevalence, incidence and years lived with disability (YLDs) for osteoarthritis (OA) in 195 countries and territories from 1990 to 2017 by age, sex and ...

Background: Patients with rheumatoid arthritis (RA) usually impaired range of motions (ROMs), especially hand and wrist active ROMs (AROMs), thus influencing their ability to perform daily activities ...

Background S100A4 belongs to a family of proteins originally defined by solubility of the prototypic members in 100% saturated ammonium sulphate. Preclinical studies suggest that extracellular S100A4 ...

Correspondence to Martin Aringer, Medicine III, University Medical Center and Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden D-01307, Germany; martin.aringer{at}uniklinikum-dresden.de; Dr ...

Background Recently, we demonstrated strong Th1 and Th17 cytokine induction by CD1c + myeloid dendritic cells (mDCs) from synovial fluid and identified thymic stromal lympopoeitin (TSLP) as an ...

Objectives The International League of Associations for Rheumatology classification criteria define systemic juvenile idiopathic arthritis (SJIA) by the presence of fever, rash and chronic arthritis.

Background SLE is a difficult to treat autoimmune disease due to clinical heterogeneity, unpredictability of disease flares and limited therapeutics. These challenges are worsened in a low-middle ...

Objective To assess the efficacy/safety of tofacitinib in adult patients with active ankylosing spondylitis (AS). Methods This phase III, randomised, double-blind, placebo-controlled study enrolled ...

Objective In the randomised scleroderma: Cyclophosphamide Or Transplantation (SCOT trial) (NCT00114530), myeloablation, followed by haematopoietic stem cell transplantation (HSCT), led to improved ...

Objectives To assess the prevalence of the main causes of morbi-mortality in the antiphospholipid syndrome (APS) during a 10-year-follow-up period and to compare the frequency of early manifestations ...

1 Department of Rheumatology, Medical School of Osmangazi University, Eskisehir, Turkey 2 Department of Rheumatology, Cerrahpasa Medical School, University of Istanbul, Turkey 3 Department of ...