Cancer Research7d
Hormone Receptor–Positive HER2-Negative/MammaPrint High-2 Breast Cancers Closely Resemble Triple-Negative Breast Cancers
1Yale Cancer Center, Yale School of Medicine, New Haven, Connecticut.
Cancer Research10d
Comparative Single-Cell Transcriptomics of Human Neuroblastoma and Preclinical Models Reveals Conservation of an Adrenergic Cell State
Copyright held by the owner/author(s). This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International ...
Cancer Research10d
PIN1 prolyl isomerase promotes initiation and progression of bladder cancer through the SREBP2-mediated cholesterol biosynthesis pathway
Salk Institute for Biological Studies, la jolla, CA, United States ...
Cancer Research8d
Bile Acids Modulate T-cell Response and Function in Liver Cancer
Major Finding: Elevated bile acids (BA) in liver cancer contribute to T-cell dysfunction. Concept: BA accumulation in T cells promotes ER stress, reducing effector function and viability. Impact: ...
Cancer Research7d
Targeting T-Cell Costimulation to the Surface of Tumor Cells
1Combination Strategies for Translational Immunotherapy, Immunology and Immunotherapy Program, Centro de Investigación Médica Aplicada (CIMA) Universidad de Navarra, Pamplona, Spain. 2Department of ...
Cancer Research6d
FDA Approves Drugs for MCL, Colorectal and Breast Cancers
Three cancer drugs separately earned FDA approval: The KRAS inhibitor sotorasib (Lumakras; Amgen) was approved for use with the EGFR inhibitor panitumumab (Vectibix; Amgen) to treat patients with ...
Cancer Research11d
Cancer Research in the Age of Spatial Omics: Lessons from IMAXT
1CRUK Cambridge Institute, University of Cambridge. Li Ka Shing Centre, Cambridge, United Kingdom.
Cancer Research11d
Atypical Small Cell Lung Cancer: A New Malignancy Characterized by Chromothripsis, Carcinoid Tumors, and Wild-type RB1 and TP53
1Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas. 2Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, ...
Cancer Research7d
A Phase II Basket Trial of Dual Anti–CTLA-4 and Anti–PD-1 Blockade in Rare Tumors SWOG S1609: Vulvar Cancers
1Northwestern University, Chicago, Illinois.
Cancer Research11d
Taking a Swing at TIMP1-Armed Immunosuppressive Astrocytes Unleashes T cell Immunity against Brain Metastases
School of Medicine, University of Leeds, Leeds, United Kingdom. *Corresponding Author: Mihaela Lorger, School of Medicine, University of Leeds, Beckett Street ...
Cancer Research11d
Nerves at Play: The Peripheral Nervous System in Extracranial Malignancies
1Sanford Research, Cancer Biology and Immunotherapies Group, Sioux Falls, South Dakota. 2Sanford School of Medicine, Health Sciences Center, University of South Dakota, Sioux Falls, South Dakota.
Cancer Research9d
Transcription Factor Fingerprint Provides Clues for Brain Tumor Cell of Origin
Department of Pathology, St. Jude Children’s Research Hospital, Memphis, Tennessee. *Corresponding Author: Brent A. Orr, Department of Pathology, St. Jude Children ...