mRNA half-life is important for mRNA surveillance and gene regulatory strategies. It has recently been shown that mRNA half-life can be estimated using high-throughput RNA-seq datasets, “without the ...

“These [changes] can define the half-life of the mRNA,” Šiurkus notes. Alternatively, researchers can also modify the chemical structure of the mRNA cap found at the molecule’s 5’ en ...

Modified nucleotides like m5C in saRNA enhance vaccine efficacy, stability, and reduce inflammation, offering a promising ...

The Food and Drug Administration approved an updated coronavirus vaccine manufactured by Novavax Friday, days after new mRNA coronavirus vaccines manufactured by Pfizer-BioNTech and Moderna ...

Annotate the specific nucleotides that drive genome folding. Train deep convolutional and recurrent neural networks to predict mRNA half-life from an mRNA sequence annotated with the first frame of ...

The Florida Department of Health, run by Surgeon General Dr. Joseph Ladapo, just released guidance on COVID-19 vaccines based ...

The data shows a significant reduction in mutant huntingtin protein in the cerebrospinal fluid of treated patients.

The mRNAs are formulated in novel patented lipid nanoparticles, which prolong the half-life of the mRNA and deliver it to immunoactive antigen-presenting cells, which enhances T-cell responses.

Therefore, rather than being a driver for TE, codon optimization may be critical for highly expressed genes due to higher demand for these tRNAs and may play a role in setting the appropriate mRNA ...

This article discusses the journeys of three gene therapy startups in South Korea, Japan, and China, and the products they ...

While analyzing the long-duration exposure, TCDF levels in the liver of mice were found to be below the detection level for GC-MS analysis, which could be attributed to the shorter half-life of TCDF.