Drugmakers had hoped that inhibiting receptor-interacting protein kinase would decrease inflammation and reduce neuronal degeneration in patients with multiple sclerosis and other neurodegenerative co ...

Targeting ceramide synthase enzymes may reduce multiple sclerosis severity by limiting ceramide C16 synthesis, offering ...

Mapping cell types in MS lesions reveals unique tissue niches and interactions, offering insights into the molecular drivers ...

Scientists say that blocking a protein called DLK could help protect against neurodegeneration of demyelinated nerve cells in ...

People with multiple sclerosis (MS) often stop taking disease-modifying ... patients tend to experience fewer relapses and less disease activity but show more evidence of neuronal degeneration.

Scientists have identified a relationship between ancient viral DNA and susceptibility to neurodegenerative diseases like ...

The pathophysiology of multiple sclerosis (MS) is characterized by demyelination, which culminates in a reduction in axonal transmission. Axonal and neuronal degeneration seem to be concomitant ...

These observations are important as neurofilament proteins are a marker of neuronal degeneration and serve as an important biomarker of disease activity in multiple sclerosis. With recent data showing ...

With its ability to improve neuron health, experimental drug NU-9 has already shown promise in reversing amyotrophic lateral ...

Reference: “Neuroprotective effect of neuron-specific deletion of the C16 ceramide synthetic enzymes in an animal model of ...

A key to their investigation was to elucidate the critical involvement of microglia in axonal degeneration post ... such as multiple sclerosis, which still remain unclear to date.