Here we explore peptide inhibitors of Cdc20, a substrate-recognition subunit and activator of the E3 ubiquitin ligase the anaphase promoting complex/cyclosome (APC/C) that is essential in mitosis and ...
Citalopram exhibits immune-dependent anti-tumor effects by modulating C5aR1 + TAMs and CD8 + T cells
This important study provides solid evidence to support the anti-tumor potential of citalopram, originally an anti-depression drug, in hepatocellular carcinoma (HCC). In addition to their previous ...
To assess cytotoxicity, PBMC or serum alone were cocultured with VX2 tumour cells. Tumour cell lysis was quantified by an adenylate kinase release assay using a luciferase assay (ToxiLight Kit, Lonza, ...
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