Growth of Kym-1 rhabdomyosarcoma cells depends on endogenous receptor ... of inhibitors of IR/IGFR kinases. Depending on the presence or absence of the caspase inhibitor z-VAD-fmk, TNF induced ...

Treprostinil signals through the IP receptor ... inhibited LPA-induced RhoA activation by 22%, however GW0742 inhibited LPA-induced RhoA activation by 37% in fibroblasts. No effect was seen with ...

Two studies reveal promising treatments for breast cancer, enhancing options for patients with triple-negative breast cancer ...

Am J Health Syst Pharm. 2008;65(15):1413-1418. Anthony Sebba, M.D., is Assistant Clinical Professor, University of South Florida, 36338 U.S. Highway 19 North, Palm ...

At the same time, Ono’s interest in the US company is likely also to be driven as much, if not more so, by vimseltinib, a CSF-1 receptor inhibitor that is due to be filed in the next few months ...

Dr. David Morris presented results from the TRITON3 study of rucaparib versus docetaxel or a second-generation androgen receptor pathway inhibitor (ARPI) in metastatic castrate-resistant prostate ...

Researchers at GSK also took a structure-based design approach to developing 3,5-dimethylisoxazole-based BET bromodomain inhibitors. Starting from 4-phenyl-3,5-dimethylisoxazole, it was shown that a ...