Note: Akt, protein kinase B; EGF, epidermal ... Note: CAR, chimeric antigen receptor; NLRP3: nod-like receptor protein three; RAAS: renin-angiotensin-aldosterone system; SGLT2-i: sodium-glucose ...

Inhibiting the entire receptor complex prevents IL-6 signal transduction to inflammatory mediators that summon B and T cells ... Since IL-6R inhibition has a distinct mechanism of action, some ...

The pre-B-cell receptor (pre-BCR ... namely monoallelic activation and feedback inhibition. Monoallelic activation prevents recombination of the gene encoding the receptor from occurring ...

Am J Health Syst Pharm. 2008;65(15):1413-1418. Anthony Sebba, M.D., is Assistant Clinical Professor, University of South Florida, 36338 U.S. Highway 19 North, Palm ...

Northeastern University has disclosed cannabinoid CB1 receptor allosteric modulators and monoglyceride lipase (MGLL; MAGL) inhibitors reported to be useful for the treatment of pain, inflammation, ...

Moexa has developed preclinical-stage SMAD3 inhibitors showing promising in vivo results against various cancers and potential applications in fibrosis. Moexa and Receptor.AI’s partnership has ...

This study presents a valuable finding on the role of secretory leukocyte protease inhibitors (SLPI) in developing Lyme disease in mice infected with Borrelia burgdorferi. The evidence supporting the ...

Sitala Bio Ltd. has prepared new indole derivatives acting as complement factor B (CFB) inhibitors. They are thus reported to be useful for the treatment of age-related macular degeneration, ...

Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to ...

Firstly, class-level effect was assessed as the second-generation androgen receptor antagonists (SGARAs) were regarded as one whole class compared with placebo through traditional meta-analysis by ...

Supernatants from pleural and ascitic fluid in patients with ovarian cancer can increase the migration activity of human melanoma cells, with subsequent inhibition after incubation of the malignant ...