G protein–coupled receptors (GPCRs) are a protein superfamily comprising >800 members that regulate numerous cellular and physiologic responses. GPCRs represent the largest class of therapeutic ...

Objective Phase II trials suggest glucagon-like peptide-1 receptor (GLP1) agonists resolve metabolic dysfunction-associated steatohepatitis but do not affect fibrosis regression. We aimed to determine ...

Background Anti-N-methyl-D-aspartate receptor encephalitis (NMDARE) is a severe autoimmune disorder with high morbidity and mortality. Current treatments have limitations including relapse, ...

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Now, scientists at the Salk Institute have pinpointed a set of transcription factors—estrogen-related receptors (ERRs)—as essential regulators of mitochondrial metabolism in skeletal muscle ...

First evidence of geometrical patterns and defined distances of biomolecules as fundamental parameters to regulate receptor binding and cell signaling have emerged recently. Here, we demonstrate the ...

In this phase 2, randomized, placebo-controlled trial, participants with narcolepsy type 1 received once- or twice-daily oveporexton (TAK-861), an oral orexin receptor 2–selective agonist ...

New research findings on oveporexton, a highly selective oral orexin receptor 2 agonist, in these patients are summarized in a short video.

Glucagon-like peptide-1 receptor agonists are linked to a reduction in alcohol intake. HealthDay News — Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are tied to a reduction in alcohol intake, ...

kDepartment of Cell and Chemical Biology, Leiden University Medical Center, Leiden, Netherlands lDepartment of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical ...

These findings could pave the way for developing pharmacological treatments targeting estrogen-related receptors (ERRs) to improve mitochondrial energy metabolism and combat human diseases associated ...