Lysophosphatidic acid (LPA) is a serum phospholipid with growth-factor-like activities for many cell types. It acts through specific G-protein-coupled receptors on the cell surface. LPA stimulates ...

J. Chun et al., "GPR92 as a new G(12/13)- and G(q)-coupled lysophosphatidic acid receptor that increases cAMP, LPA(5)," J Biol Chem, 281:23589-97, 2006. (Cited in 75 papers) Between 1996 and 2006, ...

The new research, published June 18, 2015, in the journal Cell, sheds light on the molecular architecture of receptors for a family of small fat molecules known as lysophosphatidic acid (LPA ...

D. Anderson Cancer Center in Houston believe that they have found evidence that lysophosphatidic acid (LPA) receptor expression and LPA signaling regulate the behavior and aggressiveness of ...

They identified the LPA5 receptor as the specific receptor responsible for inhibiting the immune response. In cell cultures and in mice LPA prevented signaling within cells, the appearance of ...

They identified the LPA5 receptor as the specific receptor responsible for inhibiting the immune response. In cell cultures and in mice LPA prevented signaling within cells, the appearance of ...

Thankfully, they've given that drug a name; it's now admilparant. It's an LPA receptor 1 antagonist. There's good preclinical evidence that the LPA receptor pathway plays an important role in ...

These include its lead preclinical program DJS-002, which it has been developing as a potential first-in-class lysophosphatidic acid (LPA) receptor 1 antagonist antibody for idiopathic pulmonary ...

In particular, CV risk appears highest in patients with Lp(a) >50 mg/dL who are carriers of a receptor-negative mutation in the LDLR gene, researchers reported. The aim of the SAFEHEART study was ...