Known as the mitochondrial pyruvate carrier, this molecular machine was first proposed to exist in 1971, but it has taken until now for scientists to visualise its structure at the atomic scale ...

Glycolysis, Pyruvate Oxidation and the Krebs Cycle Glycolysis, the process of splitting a six-carbon glucose molecule into two three-carbon pyruvate molecules, is linked to the Krebs cycle.

The researchers identified the structure ... pyruvate carrier (MPC), and 50 years since its discovery, have shown how it operates like the lock on a canal to transport pyruvate, a molecule ...

If these enzymes are not present or functional then the reactions will not occur, so the breakdown of glucose is controlled ... greater quantity of ATP. A pyruvate molecule enters the mitochondria ...

in which glucose is broken down or metabolized into a substance called pyruvate through a series of steps. When the body has plenty of oxygen, pyruvate is shuttled to an aerobic pathway to be ...

Investigators led by Issam Ben-Sahra, Ph.D., associate professor of Biochemistry and Molecular Genetics ... levels in the cells also decreased glucose oxidation, the cell's ability to break ...