Nolan Bianchi, John Niyo, Richard Silva and Bob Wojnowski of The Detroit News offer predictions for Monday's Lions-49ers game ...

Detroit Lions wide receiver Jameson Williams leads the NFL in yards per catch and needs 110 yards receiving in the final two ...

The San Francisco 49ers are set to host the Detroit Lions at Levi's Stadium in Santa Clara, California, on Monday, December ...

The Detroit Lions and San Francisco 49ers met 11 months ago at Levi's Stadium with a trip to the Super Bowl on the line. San Francisco used a furious second half comeback to steal the NFC Championship ...

Eleven months later as Campbell and the Lions prepare to return to Levi's Stadium for the first time since that loss, that has proved to be prophetic — for San Francisco instead of Detroit. The Lions ...

The Detroit Lions are set to play their second-to-last game of the season on the road against the San Francisco 49ers, but ...

San Francisco 49ers top scorers look to capitalize on opportunities early against Detroit Lions stout defense.

San Francisco 49ers running back Isaac Guerendo is expected to play Monday night against the Detroit Lions, according to ESPN ...

Detroit Lions coach Dan Campbell remains haunted by January's NFC Championship Game in San Francisco. For Campbell, it still ...

Spencer Burford officially has been ruled out of San Francisco's Week 17 game against the Detroit Lions on Monday night at ...

Less than a year ago, the 49ers and the Lions were the two best teams in the NFC. Now the Lions are on the verge of locking up the no. 1 seed.

As the 49ers look to play spoiler against the Lions on Monday Night Football, RB Isaac Guerendo got a positive injury update.