RhoA activity promotes cell contractility, whereas RAC1 and CDC42 signalling induces the formation of cellular protrusions. RAC1 can suppress RhoA activity and vice versa, a phenomenon that is ...

Ligand-mediated triggering of these receptors leads to the activation of the RhoGTPases Rac, Rho, and Cdc42 via GEFs and GAPs (purple zone). Such activation is highly controlled in time and space to ...

While the precise mechanisms by which tofacitinib inhibits invasion/migration is unclear, it may involve (i) inhibition of key cytokines such as IL-6 which results in negative feedback inhibition, (ii ...

This is a useful study that adds new data to how different DAG pools influence cellular signaling, and dissects how the enzyme Dip2 modulates the minor lipid signaling DAG pool, which is distinct from ...

Data are accumulating that emphasize the important role of the intestinal barrier and intestinal permeability for health and disease. However, these terms are poorly defined, their assessment is a ...

The primary node molecules in the cell signaling network in cancer tissues are maladjusted and mutated in comparison to normal tissues, which promotes the occurrence and progression of cancer.

1 Department of Gastroenterology and Hepatology, Academic Medical Centre, Amsterdam, the Netherlands 2 Department of Experimental Internal Medicine, Academic Medical Centre, Amsterdam, the Netherlands ...

The endothelium, which forms the inner lining of all blood vessels, is a highly selective barrier for blood constituents. Formation of gaps between endothelial cells (ECs), for instance during ...

Transcriptional Profiling of EC Reveals a Critical Role for Kruppel-Like Factor-2 in the Atheroprotective Response to Flow Pattern Gene microarray technology represents a powerful tool to ...

In systemic lupus erythematosus (SLE), adaptive immunity is activated by the stimulation of innate immunity, leading to the development of autoreactive T cells and activation and differentiation of B ...

Forty Hy-Line hens were obtained from the College of Animal Science and Technology of Jilin Agricultural University, which were randomly selected from the Hy-Line chicken population, and raised in ...