England vice-captain Jamie George has been ruled out of the Six Nations opener against defending champions Ireland on February 1, the Rugby Football Union announced on Tuesday.

England lose Jamie George for Six Nations opener as injuries mount before Ireland clash - Alex Mitchell is also doubtful for Dublin trip, with Alex Coles, Jack van Poortvliet and Alex Dombrandt all ru

Vice-captain Jamie George heads England withdrawals for Six Nations opener - Influential scrum-half Alex Mitchell is a doubt for the opener against Ireland on February 1.

Maro Itoje replaces Jamie George as England captain for Six Nations - George has been in charge since the 2023 World Cup but is demoted to vice-skipper alongside Ellis Genge.

England have suffered significant injury news ahead of the Six Nations with Jamie George set to miss their opening fixture against Ireland. Hooker George, who has been replaced by Maro Itoje as captain,

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Scotland have added five players to their Six Nations squad ahead of their opening fixture against Italy at Murrayfield on Saturday, including Australia-born back row Alexander Masibaka after number eight Josh Bayliss dropped out with a groin injury.

England’s third game of the 2025 Six Nations Championship will see them face Scotland at Twickenham. Scotland have won the last four Six Nations meetings against the Auld Enemy, including a 30-21 victory at Murrayfield last year.

Alex Mitchell limped out of Northampton's Champions Cup final pool round victory against Munster and was a doubt to play in the championship opener in Dublin

England have been hit by the loss of vice-captain Jamie George for their Guinness Six Nations opener against Ireland on February 1, with Alex Mitchell also a doubt for the Dublin showdown. Hooker George suffered a hamstring injury in Saracens’ Investec Champions Cup defeat by Saracens on Sunday and will miss the start of the tournament,

January is almost over and the 25th edition of the Six Nations is about to lift the gloom. To celebrate, here are 25 reasons to be cheerful, from tactical nuances to star players and a potentially blockbuster television pundit.

The void left by Tuipulotu is clear but there is now an opportunity to try new combinations and shock their Six Nations opponents