Professor Hirohide Saito and his research team have developed a new microRNA-responsive hybrid mRNA switch, enabling precise, ...

Join the 3rd mRNA Process Development Summit Europe to connect with over 100 experts in upstream and downstream process development.

Researchers at the University of Würzburg have discovered a process that breaks down mRNA molecules in the human body particularly efficiently. This could be useful, for example, in the treatment ...

Some of these innovative applications in the mRNA space include using circular RNA in the production process to enhance RNA stability and cell-based analytical methods to test for immunogenicity.

The mRNA therapeutics field is rapidly evolving beyond vaccines to include treatments for cancer, genetic disorders and in vivo cell therapies, bringing with it diverse production challenges. As the ...

However, production of the mRNA used in vaccines is hindered by its production, which involves both chemical synthesis and a slower enzyme-mediated process.

The US Food and Drug Administration’s top vaccine official overrode agency experts in May to recommend against the broad use ...

One of mRNA’s greatest advantages is the ability to rapidly iterate and optimize sequences, accelerating drug discovery and development. Advances in cell-free gene synthesis and in vitro transcription ...

Figure 2: Options in a typical mRNA synthesis workflow Following mRNA synthesis, encapsulation (Figure 3) is a key step in the process to deliver mRNA into the target cells. Lipid nanoparticles ...

We believe that Linea IVT supports the promise of mRNA and its potential to create a new generation of transformative medicines, such as mRNA therapeutics, vaccines, and personalized therapies." ...