In the fight against diseases like Alzheimer’s and Parkinson’s, scientists have long struggled to predict how certain ...

Such amyloid beta fibrils are one of the hallmarks of ... and solid-state nuclear magnetic resonance (NMR) to determine its structure. Their research is published in Nature Communications.

We examined acetylcholinesterase, plasma neuronal proteins, secreted beta-amyloid precursor protein (APP), and amyloid-beta 40 and amyloid-beta 42 peptides in children with and without autism.

These emerging concepts are exemplified by Alzheimer's disease, in which amyloid β-protein oligomers adversely affect synaptic structure and plasticity. Findings in other neurodegenerative ...

Cite this: Neuro-Inflammation Induced By Lipopolysaccharide Causes Cognitive Impairment Through Enhancement Of Beta-Amyloid Generation - Medscape - Aug 29, 2008.

Using CRISPR gene editing, the team modified human microglia to secrete neprilysin—an enzyme known to degrade beta-amyloid—under the control of a promoter that only activates near plaques.

Despite an R&D spend of around $15bn, a total of 20 beta amyloid protein-targeting drugs have failed to show efficacy in phase II and III studies involving AD patients, and pharma companies are ...