Proline plays an important role in mediating protein folding and stability, however, the impact of noncanonical proline analogues on protein folding and stability is not well understood.

Incorporating the amino acid building block proline into the nascent protein molecule presents a particular challenge for the cell during protein biosynthesis. Due to its rigid structure ...

must be added (assuming a proline content of protein of 9% and 2 g/kg/d net protein synthesis), suggesting a total molar requirement for arginine plus proline of 2.4 mmol/kg/d. The sum of the ...

During protein biosynthesis, cells face a challenge in incorporating the amino acid proline into growing protein chains. Proline’s rigid structure often causes stalling at the ribosomes—the ...