This incredible array of functions derives from a startlingly simple code that specifies a hugely diverse set of structures ... proteins can interfere with proper folding and cause large ...

Proteins are fundamental biomolecules that perform a broad range of vital functions within the human body. They serve as an essential structural and functional component of cells, tissues and organs ...

Since the 1970s, researchers worldwide have been compiling information on the structures of approximately 200,000 distinct proteins, which contributed to the AlphaFold breakthrough.

Much of the difficulty of determining the contributions of individual residues to protein structure and function stems from the need to generate and evaluate a large number of mutants. The ...