Three protein kinases (ATP:protein phosphotransferase, EC 2.7.1.37) were detected when the soluble fraction of rabbit kidney medulla was chromatographed on DEAE-cellulose with a linear NaCl gradient.

PNAS is the world's most-cited multidisciplinary scientific serial. It publishes high-impact research reports, commentaries, perspectives, reviews, colloquium papers, and actions of the Academy. In ...

The second messenger cyclic di-AMP (c-di-AMP) plays a pivotal role in bacterial physiology by regulating osmolyte transport, potassium uptake, cell wall integrity and the overall stress response.

THE biologic role of cyclic AMP (adenosine 3′,5′-monophosphate), at least as it is understood today, is shown in Figure 1. After release from an endocrine gland, a hormone is transported to its ...

Protein kinases are a large family of regulatory enzymes that change multiple processes in cells by addition of inorganic phosphate to other proteins. All eukaryotic protein kinases share a conserved ...