The experiments revealed that the antidepressant-like effects were primarily mediated by Akt signaling in the mPFC, while the anxiolytic effects were associated with activation of the amygdala ...

This finding indicates that BRD7 plays a role in an insulin signaling pathway independent of the pathway of the insulin receptor substrate-AKT axis. Park and colleagues are now back to work.

Researchers from SRM Institute of Science and Technology, led by Dr. KN Aruljothi, have published a study in ExRNA ...

Plectin drives hepatocellular carcinoma progression and metastasis through cytoskeletal reorganization and oncogenic signaling, making it a promising therapeutic target for overcoming therapy ...

We have shown that tumors with HER2 amplification or PI3K mutation are selectively dependent for growth on the PI3K pathway and are sensitive to specific inhibitors of PI3K or AKT. Inhibition of PI3K ...