Akhisar is a municipality and district of Manisa Province, Turkey. Its area is 1,645 km, and its population is 177,419. It is the site of the ancient cit…Akhisar is a municipality and district of Manisa Province, Turkey. Its area is 1,645 km, and its population is 177,419. It is the site of the ancient city of Thyatira. With archaeological findings that are proving settlements going back to 3000 BC, Akhisar has been a busy trade center with its strategic location at the intersection of important roads during ancient and medieval ages. Akhisar also hosted one of the Seven churches of Asia: Thyatira, which is mentioned in the Bible. Akhisar maintained its importance as a regional trade center during the Ottoman period.